Longevity Starts in Your Skeleton: The Science of Bone Health and Hormones

October 20, 2025 · Shawn Sprague, PT, DPT, OCS · 4 min read

LongevityNutrition

In this issue
  • Guest contributor explores how hormones and daily habits shape bone health and long-term strength
  • Another construction update!

Protecting Bone Health for Longevity: Hormones & Habits

Osteoporosis, low bone mass resulting in increased fragility and related fractures, are among the leading causes of death and disability with age. Osteoporosis disproportionally affects women, and early prevention is key to improving long term outcomes.

Here is a little-known fact: many fractures are pathologic in nature meaning it is the bone that gives way first, and the resulting instability leads to a fall not vice versa. With weakened, osteoporotic bones, even a minor misstep can be enough to cause such an event.

Here’s the bad news ... you can’t feel osteoporosis and often by the time it’s diagnosed, significant bone loss has already occurred. Now the good news... both hormones and habits can dramatically change the trajectory of bone and muscle health, protecting mobility and vitality for years to come.

Hormones: Your Internal Protectors

· Estrogen helps slow bone breakdown and supports bone-building cells. After menopause, the sharp decline in estrogen accelerates bone loss. Estrogen therapy has been shown to protect against osteoporosis and reduce fracture risk, but it is important to note that the protective effect lasts only while treatment continues. If estrogen is discontinued, bone loss resumes.

· Progesterone works in concert with estrogen to help regulate the bone remodeling cycle and may provide additional protection when combined with estrogen therapy. In women with a uterus, progesterone is typically prescribed alongside estrogen to protect the endometrium; however, it may also play a role in bone health.

· Testosterone supports muscle mass, strength, and energy in both men and women. Stronger muscles lower the risk of falling and, in turn, the chance of a fracture. Testosterone also directly contributes to bone density. Stay tuned for an upcoming newsletter delving further into testosterone therapy for women.

Habits: Your Everyday Defense System

· Strength training is the single best exercise you can do for your bones and muscles because it stimulates bone growth and builds muscle, both of which are essential for preventing falls and fractures. The sooner you start, the better: it’s much easier to build and maintain muscle earlier in life than to try to regain it after it’s been lost. Start training now to stay strong and protected for years to come.

o A note on grip strength. Grip strength is often used as a marker of overall muscle strength and is strongly linked to longevity. Just as importantly, it reflects your ability to catch yourself during a fall, a critical skill for preventing fractures. Functional strength training naturally incorporates exercises that build grip strength, making it one of the most effective forms of strength training for anyone focused on long-term health and vitality.

· Protein serves as the building block of muscle and adequate intake is essential. As we age, our bodies experience anabolic resistance, meaning it takes more to stimulate muscle growth. Consistently meeting your protein needs (which increase with age) helps preserve both muscle strength and bone integrity over time.

· Supplements can be helpful when addressing deficiencies, but they are not one-size-fits-all. Because supplements are not strictly regulated, quality can vary widely between sources. Determining which supplements are appropriate for you and monitoring their use over time is essential. Some supplements that are particularly relevant to muscle/bone health are as follows:

o Vitamin D → supports calcium absorption and bone metabolism

o Calcium → critical for bone mineralization if dietary intake is low

o Magnesium & Vitamin K2 → help guide calcium into bones (not soft tissues)

o Creatine → supports muscle strength, exercise performance, and muscle recovery

o Protein supplements→ convenient ways to close nutritional gaps if needed

o Collagen→ may support joints/connective tissue

· Habits to avoid → smoking, excess alcohol, high stress, poor sleep, inadequate nutrition, and excessive caffeine intake. Any one of these habits alone is harmful to bone health but together they can create a perfect storm making bones more fragile and more likely to break even from minor falls or everyday activities.

The Bottom Line

Hormones like estrogen, progesterone, and testosterone protect your skeleton from the inside. Habits like strength training, protein intake, smart supplementation, etc. reinforce protection from the outside.

Together, they form a powerful shield against fractures, frailty, and loss of independence. Taking steps now to strengthen and preserve your bones and muscles is one of the most effective strategies for long-term health and longevity.

Note: This information is intended for educational purposes only and should not be taken as medical advice. Please consult with a qualified healthcare provider to determine what interventions are right for you.

Bridget Hagen, DNP, APRN, FNP-C

Wellesley Testosterone

wellesleytestosterone.com


Construction Update!

Painting is wrapping up, mirrors are in, and the electricians have finished—we officially have lights! The last finishing touches are underway as we prepare for the final step: new flooring throughout both the existing and new spaces.

We’ll be closed from November 3rd–5th while the flooring is installed, afterwards all the interior work will be finished and equipment will start to arrive the week after. Stay tuned for more!


Learn More From Us!

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This is an archived newsletter issue, published as originally sent. Information here is general and isn't medical advice for your particular situation. If something hurts, come and talk to us. Book a free fit call.